Ontology highlight
ABSTRACT:
SUBMITTER: Charpak-Amikam Y
PROVIDER: S-EPMC5561058 | biostudies-literature | 2017 Aug
REPOSITORIES: biostudies-literature
Charpak-Amikam Yoav Y Kubsch Tobias T Seidel Einat E Oiknine-Djian Esther E Cavaletto Noemi N Yamin Rachel R Schmiedel Dominik D Wolf Dana D Gribaudo Giorgio G Messerle Martin M Cicin-Sain Luka L Mandelboim Ofer O
Scientific reports 20170817 1
Human cytomegalovirus (HCMV) is a major human pathogen, causing serious diseases in immunocompromised populations and congenially infected neonates. One of the main immune cells acting against the virus are Natural Killer (NK) cells. Killing by NK cells is mediated by a small family of activating receptors such as NKp30 that interact with the cellular ligand B7-H6. The outcome of B7-H6-NKp30 interaction was, so far, mainly studied with regard to NK recognition and killing of tumors. Here, we dem ...[more]