Ontology highlight
ABSTRACT:
SUBMITTER: Kobayashi D
PROVIDER: S-EPMC5561199 | biostudies-literature | 2017 Aug
REPOSITORIES: biostudies-literature
Kobayashi Daichi D Endo Masataka M Ochi Hirotaka H Hojo Hironobu H Miyasaka Masayuki M Hayasaka Haruko H
Scientific reports 20170817 1
The chemokine receptor CCR7 contributes to various physiological and pathological processes including T cell maturation, T cell migration from the blood into secondary lymphoid tissues, and tumor cell metastasis to lymph nodes. Although a previous study suggested that the efficacy of CCR7 ligand-dependent T cell migration correlates with CCR7 homo- and heterodimer formation, the exact extent of contribution of the CCR7 dimerization remains unclear. Here, by inducing or disrupting CCR7 dimers, we ...[more]