Protein microarray analysis identifies key cytokines associated with malignant middle cerebral artery infarction.

ABSTRACT:

Introduction

We aimed to explore potential cytokines involved in the malignant middle cerebral artery infarction (MMI) and elucidate their underlying regulatory mechanisms.

Methods

We first developed a cytokine profile by Quantibody^® Human Cytokine Antibody Array7000 using serum samples from eight patients with MMI and eight patients with non-acute cerebral infarction (NACI). The differentially expressed cytokines were then identified in patients with MMI using two-tailed Student's t-test and Fisher's Exact Test compared with patients with NACI. Gene Ontology and pathway enrichment analyses were performed using DAVID. Protein-protein interaction (PPI) network was constructed based on STRING database.

Results

A total of 10 differentially expressed cyt

SUBMITTER: Zhou Z 

PROVIDER: S-EPMC5561308 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature