Effect of systolic blood pressure reduction on hematoma expansion, perihematomal edema, and 3-month outcome among patients with intracerebral hemorrhage: results from the antihypertensive treatment of acute cerebral hemorrhage study.

ABSTRACT:

Background

Evidence indicates that systolic blood pressure (SBP) reduction may reduce hematoma expansion in patients with intracerebral hemorrhage (ICH) who are initially seen with acute hypertensive response.

Objective

To explore the relationship between different variables of SBP reduction and hematoma expansion, perihematomal edema, and 3-month outcome among patients with ICH.

Design

Post hoc analysis of a traditional phase 1 dose-escalation multicenter prospective study.

Setting

Emergency departments and intensive care units.

Patients

Patients having ICH with an elevated SBP of at least 170 mm Hg who were seen within 6 hours of symptom onset.

Intervention

Systolic blood pressure reduction using intravenous nicardipine hydrochloride targeting 3

SUBMITTER: Qureshi AI 

PROVIDER: S-EPMC5562043 | biostudies-literature | 2010 May

REPOSITORIES: biostudies-literature