Ontology highlight
ABSTRACT:
SUBMITTER: Li QG
PROVIDER: S-EPMC5562223 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Li Qi-Gang QG He Yong-Han YH Wu Huan H Yang Cui-Ping CP Pu Shao-Yan SY Fan Song-Qing SQ Jiang Li-Ping LP Shen Qiu-Shuo QS Wang Xiao-Xiong XX Chen Xiao-Qiong XQ Yu Qin Q Li Ying Y Sun Chang C Wang Xiangting X Zhou Jumin J Li Hai-Peng HP Chen Yong-Bin YB Kong Qing-Peng QP
Theranostics 20170708 11
Heterogeneity in transcriptional data hampers the identification of differentially expressed genes (DEGs) and understanding of cancer, essentially because current methods rely on cross-sample normalization and/or distribution assumption-both sensitive to heterogeneous values. Here, we developed a new method, Cross-Value Association Analysis (CVAA), which overcomes the limitation and is more robust to heterogeneous data than the other methods. Applying CVAA to a more complex pan-cancer dataset co ...[more]