Ontology highlight
ABSTRACT:
SUBMITTER: Alam SM
PROVIDER: S-EPMC5562351 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Science translational medicine 20170301 381
A goal for an HIV-1 vaccine is to overcome virus variability by inducing broadly neutralizing antibodies (bnAbs). One key target of bnAbs is the glycan-polypeptide at the base of the envelope (Env) third variable loop (V3). We have designed and synthesized a homogeneous minimal immunogen with high-mannose glycans reflective of a native Env V3-glycan bnAb epitope (Man<sub>9</sub>-V3). V3-glycan bnAbs bound to Man<sub>9</sub>-V3 glycopeptide and native-like gp140 trimers with similar affinities. F ...[more]