Ontology highlight
ABSTRACT:
SUBMITTER: Coulson GB
PROVIDER: S-EPMC5562523 | biostudies-literature | 2017 Aug
REPOSITORIES: biostudies-literature
Cell chemical biology 20170803 8
Mycobacterium tuberculosis (Mtb) must sense and adapt to immune pressures such as acidic pH during pathogenesis. The goal of this study was to isolate compounds that inhibit acidic pH resistance, thus defining virulence pathways that are vulnerable to chemotherapy. Here, we report that the compound AC2P36 selectively kills Mtb at acidic pH and potentiates the bactericidal activity of isoniazid, clofazimine, and diamide. We show that AC2P36 activity is associated with thiol stress and causes an e ...[more]