Genes in the serotonin pathway are associated with bipolar affective disorder in a Han Chinese population.
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ABSTRACT:
SUBMITTER: Xiang B
PROVIDER: S-EPMC5562572 | biostudies-literature | 2014 Feb
REPOSITORIES: biostudies-literature
Publications
Genes in the serotonin pathway are associated with bipolar affective disorder in a Han Chinese population.
Xiang Bo B Yang Zhenxing Z Lin Yin Y Guan Lijie L Li Xuan X Deng Wei W Jiang Zeyu Z Lao Guohui G Wang Qiang Q Hao Xiaoyu X Liu Xiang X Wang Yingcheng Y Zhao Liansheng L Ma Xiaohong X Li Tao T Cao Liping L Hu Xun X
Neuroscience bulletin 20131017 1
Serotonin plays an important role in mood regulation, but the involvement of serotonin pathway genes in the development of bipolar I disorder (BP-I), a mood disorder, is not clear. We selected 21 single-nucleotide polymorphisms (SNPs) within the HTR2A gene, 8 within the SLC6A4 gene and 23 within the TPH2 gene for genotyping using the GoldenGate genotyping assay. A total of 375 patients with BP-I and 475 normal controls were recruited. Two out of 21 SNPs (rs1475196 and rs9567747) in the HTR2A gen ...[more]
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