Association of Matrix Gla protein gene (rs1800801, rs1800802, rs4236) polymorphism with vascular calcification and atherosclerotic disease: a meta-analysis.

ABSTRACT: Association between the MGP gene rs1800801, rs1800802, rs4236 polymorphisms and vascular calcification and atherosclerotic disease was inconsistent. To clarify precise association, we performed this meta-analysis. Medline, Embase and China Knowledge Resource Integrated Database were systematically searched through December 2016. A total of 23 case-control studies, consisting of 5280 cases and 5773 controls, were included. The overall results suggested that the -7A polymorphism was associated with an increased risk for vascular calcification and atherosclerotic disease in the recessive model (OR?=?1.50, 95% CI 1.01-2.24, P?=?0.045). Subgroup analyses of Caucasians showed significant associations in the allelic model, recessive model, and homozygote model: allelic model (OR?=?1.19, 95% CI 1.06-1.34, P?=?0.004), recessive model (OR?=?1.60, 95% CI 1.26-2.03, P?

SUBMITTER: Sheng K 

PROVIDER: S-EPMC5562806 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature