Ontology highlight
ABSTRACT:
SUBMITTER: Elegheert J
PROVIDER: S-EPMC5563082 | biostudies-literature | 2017 Aug
REPOSITORIES: biostudies-literature
Neuron 20170801 4
Neuroligin-neurexin (NL-NRX) complexes are fundamental synaptic organizers in the central nervous system. An accurate spatial and temporal control of NL-NRX signaling is crucial to balance excitatory and inhibitory neurotransmission, and perturbations are linked with neurodevelopmental and psychiatric disorders. MDGA proteins bind NLs and control their function and interaction with NRXs via unknown mechanisms. Here, we report crystal structures of MDGA1, the NL1-MDGA1 complex, and a spliced NL1 ...[more]