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Wave-CAIPI for highly accelerated MP-RAGE imaging.

ABSTRACT: PURPOSE:To introduce a highly accelerated T1-weighted magnetization-prepared rapid gradient echo (MP-RAGE) acquisition that uses wave-controlled aliasing in parallel imaging (wave-CAIPI) encoding to retain high image quality. METHODS:Significant acceleration of the MP-RAGE sequence is demonstrated using the wave-CAIPI technique. Here, sinusoidal waveforms are used to spread aliasing in all three directions to improve the g-factor. Combined with a rapid (2 s) coil sensitivity acquisition and data-driven trajectory calibration, we propose an online integrated acquisition-reconstruction pipeline for highly efficient MP-RAGE imaging. RESULTS:The 9-fold accelerated MP-RAGE acquisition can be performed in 71 s, with a maximum and average g-factor of gmax ?=?1.27 and gavg ?=?1.06 at 3T. Compared with the state-of-the-art method controlled aliasing in parallel imaging results in higher acceleration (2D-CAIPIRINHA), this is a factor of 4.6/1.4 improvement in gmax /gavg . In addition, we demonstrate a 57 s acquisition at 7T with 12-fold acceleration. This acquisition has a g-factor performance of gmax ?=?1.15 and gavg ?=?1.04. CONCLUSION:Wave encoding overcomes the g-factor noise amplification penalty and allows for an order of magnitude acceleration of MP-RAGE acquisitions. Magn Reson Med 79:401-406, 2018. © 2017 International Society for Magnetic Resonance in Medicine.

SUBMITTER: Polak D

PROVIDER: S-EPMC5563495 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature

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Wave-CAIPI for highly accelerated MP-RAGE imaging.

Polak Daniel D Setsompop Kawin K Cauley Stephen F SF Gagoski Borjan A BA Bhat Himanshu H Maier Florian F Bachert Peter P Wald Lawrence L LL Bilgic Berkin B

Magnetic resonance in medicine 20170220 1

<h4>Purpose</h4>To introduce a highly accelerated T1-weighted magnetization-prepared rapid gradient echo (MP-RAGE) acquisition that uses wave-controlled aliasing in parallel imaging (wave-CAIPI) encoding to retain high image quality.<h4>Methods</h4>Significant acceleration of the MP-RAGE sequence is demonstrated using the wave-CAIPI technique. Here, sinusoidal waveforms are used to spread aliasing in all three directions to improve the g-factor. Combined with a rapid (2 s) coil sensitivity acqui ...[more]

PMID: 28220617

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Project description:BACKGROUND:Rapid volumetric imaging protocols could better utilize limited scanner resources. PURPOSE:To develop and validate an optimized 6-minute high-resolution volumetric brain MRI examination using Wave-CAIPI encoding. STUDY TYPE:Prospective. POPULATION/SUBJECTS:Ten healthy subjects and 20 patients with a variety of intracranial pathologies. FIELD STRENGTH/SEQUENCE:At 3?T, MPRAGE, T2 -weighted SPACE, SPACE FLAIR, and SWI were acquired at 9-fold acceleration using Wave-CAIPI and for comparison at 2-4-fold acceleration using conventional GRAPPA. ASSESSMENT:Extensive simulations were performed to optimize the Wave-CAIPI protocol and minimize both g-factor noise amplification and potential T1 /T2 blurring artifacts. Moreover, refinements in the autocalibrated reconstruction of Wave-CAIPI were developed to ensure high-quality reconstructions in the presence of gradient imperfections. In a randomized and blinded fashion, three neuroradiologists assessed the diagnostic quality of the optimized 6-minute Wave-CAIPI exam and compared it to the roughly 3× slower GRAPPA accelerated protocol using both an individual and head-to-head analysis. STATISTICAL TEST:A noninferiority test was used to test whether the diagnostic quality of Wave-CAIPI was noninferior to the GRAPPA acquisition, with a 15% noninferiority margin. RESULTS:Among all sequences, Wave-CAIPI achieved negligible g-factor noise amplification (gavg ???1.04) and burring artifacts from T1 /T2 relaxation. Improvements of our autocalibration approach for gradient imperfections enabled increased robustness to gradient mixing imperfections in tilted-field of view (FOV) prescriptions as well as variations in gradient and analog-to-digital converter (ADC) sampling rates. In the clinical evaluation, Wave-CAIPI achieved similar mean scores when compared with GRAPPA (MPRAGE: ØW ?=?4.03, ØG ?=?3.97; T2 w SPACE: ØW ?=?4.00, ØG ?=?4.00; SPACE FLAIR: ØW ?= 3.97, ØG ?=?3.97; SWI: ØW ?=?3.93, ØG ?=?3.83) and was statistically noninferior (N?=?30, P?<?0.05 for all sequences). DATA CONCLUSION:The proposed volumetric brain exam retained comparable image quality when compared with the much longer conventional protocol. LEVEL OF EVIDENCE:2 Technical Efficacy: Stage 1 J. Magn. Reson. Imaging 2019;50:961-974.

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Wave-CAIPI for highly accelerated MP-RAGE imaging.

Publications

Wave-CAIPI for highly accelerated MP-RAGE imaging.

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