Viral polymerase inhibitors T-705 and T-1105 are potential inhibitors of Zika virus replication.
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ABSTRACT:
SUBMITTER: Cai L
PROVIDER: S-EPMC5563514 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
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Viral polymerase inhibitors T-705 and T-1105 are potential inhibitors of Zika virus replication.
Cai Lei L Sun Yajie Y Song Yabin Y Xu Likun L Bei Zhuchun Z Zhang Dongna D Dou Yuanyuan Y Wang Hongquan H
Archives of virology 20170608 9
Since 2015, 69 countries and territories have reported evidence of vector-borne Zika virus (ZIKV) transmission. Currently, there are no effective licensed vaccines or drugs available for the treatment or prevention of ZIKV infection. We tested a series of compounds for their ability to inhibit ZIKV replication in cell culture. The compounds in T-705 (favipiravir) and T-1105 were found to have antiviral activity, suggesting that these compounds are promising candidates for further development as ...[more]
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