Ontology highlight
ABSTRACT:
SUBMITTER: Tavernier SJ
PROVIDER: S-EPMC5563826 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
Tavernier Simon J SJ Osorio Fabiola F Vandersarren Lana L Vetters Jessica J Vanlangenakker Nele N Van Isterdael Gert G Vergote Karl K De Rycke Riet R Parthoens Eef E van de Laar Lianne L Iwawaki Takao T Del Valle Juan R JR Hu Chih-Chi Andrew CC Lambrecht Bart N BN Janssens Sophie S
Nature cell biology 20170501 6
The IRE1-XBP1 signalling pathway is part of a cellular programme that protects against endoplasmic reticulum (ER) stress, but also controls development and survival of immune cells. Loss of XBP1 in splenic type 1 conventional dendritic cells (cDC1s) results in functional alterations without affecting cell survival. However, in mucosal cDC1s, loss of XBP1 impaired survival in a tissue-specific manner-while lung cDC1s die, intestinal cDC1s survive. This was not caused by differential activation of ...[more]