Ontology highlight
ABSTRACT:
SUBMITTER: Jia X
PROVIDER: S-EPMC5563834 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
Neuroscience bulletin 20160915 6
The dopamine transporter (DAT) is involved in the regulation of extracellular dopamine levels. A 40-bp variable-number tandem repeat (VNTR) polymorphism in the 3'-untranslated region (3'UTR) of the DAT has been reported to be associated with various phenotypes that are involved in the aberrant regulation of dopaminergic neurotransmission. In the present study, we found that miR-137 and miR-491 caused a marked reduction of DAT expression, thereby influencing neuronal dopamine transport. Moreover, ...[more]