Ontology highlight
ABSTRACT:
SUBMITTER: Sabio G
PROVIDER: S-EPMC556394 | biostudies-literature | 2005 Mar
REPOSITORIES: biostudies-literature
The EMBO journal 20050224 6
Activation of the p38 MAP kinase pathways is crucial for the adaptation of mammalian cells to changes in the osmolarity of the environment. Here we identify SAP97/hDlg, the mammalian homologue of the Drosophila tumour suppressor Dlg, as a physiological substrate for the p38gamma MAP kinase (SAPK3/p38gamma) isoform. SAP97/hDlg is a scaffold protein that forms multiprotein complexes with a variety of proteins and is targeted to the cytoskeleton by its association with the protein guanylate kinase- ...[more]