Ontology highlight
ABSTRACT:
SUBMITTER: Racanicchi S
PROVIDER: S-EPMC556397 | biostudies-literature | 2005 Mar
REPOSITORIES: biostudies-literature
Racanicchi Serena S Maccherani Chiara C Liberatore Concetta C Billi Monia M Gelmetti Vania V Panigada Maddalena M Rizzo Giovanni G Nervi Clara C Grignani Francesco F
The EMBO journal 20050224 6
The AML1/ETO and PML/RARalpha leukemia fusion proteins induce acute myeloid leukemia by acting as transcriptional repressors. They interact with corepressors, such as N-CoR and SMRT, that recruit a multiprotein complex containing histone deacetylases on crucial myeloid differentiation genes. This leads to gene repression contributing to generate a differentiation block. We expressed in leukemia cells containing PML/RARalpha and AML1/ETO N-CoR protein fragments derived from fusion protein/corepre ...[more]