Ontology highlight
ABSTRACT:
SUBMITTER: Zhai W
PROVIDER: S-EPMC5563985 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Zhai Wei W Sun Yin Y Guo Changcheng C Hu Guanghui G Wang Mingchao M Zheng Jiayi J Lin WanYing W Huang Qingbo Q Li Gonghui G Zheng Junhua J Chang Chawnshang C
Cell death and differentiation 20170623 9
While the androgen receptor (AR) might promote renal cell carcinoma (RCC) initiation and progression, the molecular mechanisms involved remain largely unclear. Here, we discovered the novel LncRNA-SARCC, which was suppressed and associated with better prognosis in RCC. Preclinical studies using multiple RCC cells and in vivo mouse model indicated that LncRNA-SARCC could attenuate RCC cell invasion, migration and proliferation in vitro and in vivo. Mechanistically, LncRNA-SARCC bound and destabil ...[more]