Ontology highlight
ABSTRACT:
SUBMITTER: Imielinski M
PROVIDER: S-EPMC5564321 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Imielinski Marcin M Guo Guangwu G Meyerson Matthew M
Cell 20170112 3
Certain cell types function as factories, secreting large quantities of one or more proteins that are central to the physiology of the respective organ. Examples include surfactant proteins in lung alveoli, albumin in liver parenchyma, and lipase in the stomach lining. Whole-genome sequencing analysis of lung adenocarcinomas revealed noncoding somatic mutational hotspots near VMP1/MIR21 and indel hotspots in surfactant protein genes (SFTPA1, SFTPB, and SFTPC). Extrapolation to other solid cancer ...[more]