Ontology highlight
ABSTRACT:
SUBMITTER: Jones BL
PROVIDER: S-EPMC5564401 | biostudies-literature | 2013 Jul
REPOSITORIES: biostudies-literature
Journal of clinical pharmacology 20130516 7
Histamine iontophoresis with laser Doppler monitoring (HILD) is a robust and dynamic surrogate for histamine microvasculature response. We characterized histamine pharmacodynamics in children using HILD. HILD was performed in 54 children with allergic rhinitis. A non-compartmental analysis and non-linear mixed-effects model with a linked effect PK/PD model was used to provide estimates for area under the effect curve (AUEC), maximal response over baseline (EffmaxNT), and time of EffmaxNT (Tmax). ...[more]