Pharmacokinetics of metoprolol during pregnancy and lactation.
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ABSTRACT:
SUBMITTER: Ryu RJ
PROVIDER: S-EPMC5564514 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
Publications
Pharmacokinetics of metoprolol during pregnancy and lactation.
Ryu Rachel J RJ Eyal Sara S Easterling Thomas R TR Caritis Steve N SN Venkataraman Raman R Hankins Gary G Rytting Erik E Thummel Kenneth K Kelly Edward J EJ Risler Linda L Phillips Brian B Honaker Matthew T MT Shen Danny D DD Hebert Mary F MF
Journal of clinical pharmacology 20151204 5
The objective of this study was to evaluate the steady-state pharmacokinetics of metoprolol during pregnancy and lactation. Serial plasma, urine, and breast milk concentrations of metoprolol and its metabolite, α-hydroxymetoprolol, were measured over 1 dosing interval in women treated with metoprolol (25-750 mg/day) during early pregnancy (n = 4), mid-pregnancy (n = 14), and late pregnancy (n = 15), as well as postpartum (n = 9) with (n = 4) and without (n = 5) lactation. Subjects were genotyped ...[more]
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