Ontology highlight
ABSTRACT:
SUBMITTER: Yang H
PROVIDER: S-EPMC5564565 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
Oncotarget 20170701 29
This study mainly studied the effect of inhibition of nuclear factor-κB (NF-κB) signal by pyrrolidine dithiocarbamate (PDTC) on lipopolysaccharide (LPS)-induced inflammatory response, oxidative stress, and mitochondrial dysfunction in a murine acute lung injury model. The results showed that LPS exposure activated NF-κB and its upstream proteins and caused lung inflammation, oxidative stress, and mitochondrial dysfunction in mice. While inhibition of NF-κB by PDTC adminstration alleviated LPS-in ...[more]