Ontology highlight
ABSTRACT:
SUBMITTER: Luo X
PROVIDER: S-EPMC5564732 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
Luo Xinrong X Xiong Xin X Shao Qing Q Xiang Tingxiu T Li Lili L Yin Xuedong X Li Xia X Tao Qian Q Ren Guosheng G
Oncotarget 20170701 30
Interferon (IFN) regulatory factor 8 is encoded by a novel candidate tumor suppressor gene (IRF8), its promotor is frequently methylated in multiple cancers. However, the promoter methylation status, functions and underlying mechanisms of IRF8 in breast cancer remain unclear. We found that IRF8 was downregulated in breast cancer cell lines and primary tumors, compared with normal breast tissues, mainly because of aberrant promoter methylation. However, its expression was not associated with path ...[more]