Ontology highlight
ABSTRACT:
SUBMITTER: Dos Santos SN
PROVIDER: S-EPMC5564783 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
Dos Santos Sofia Nascimento SN Sheldon Helen H Pereira Jonathas Xavier JX Paluch Christopher C Bridges Esther M EM El-Cheikh Márcia Curry MC Harris Adrian L AL Bernardes Emerson Soares ES
Oncotarget 20170701 30
Angiogenesis is a coordinated process tightly regulated by the balance between Delta-like-4 (DLL4) and Jagged-1 (JAG1) in endothelial cells. Here we show that galectin-3 (gal-3), a glycan-binding protein secreted by cancer cells under hypoxic conditions, triggers sprouting angiogenesis, assisted by hypoxic changes in the glycosylation status of endothelial cells that enhance binding to gal-3. Galectin-3's proangiogenic functions were found to be predominantly dependent on the Notch ligand JAG1. ...[more]