Ontology highlight
ABSTRACT: Ac/cc
OR = 1.50; (95% CI: 1.24-1.81), P = 0.530; C vs. A: OR=1.22, (95%CI:1.11-1.34), P = 0.159]. Furthermore, stratified analyses by ethnicity indicated a significant association only in the Asian population. Our results indicate that the ERCC2 Lys751Gln polymorphism might be important in stimulating the development of pancreatic cancer, especially for Asians.
SUBMITTER: Wu Y
PROVIDER: S-EPMC5564835 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
Wu Yang Y Lu Zi-Peng ZP Zhang Jing-Jing JJ Liu Dong-Fang DF Shi Guo-Dong GD Zhang Chun C Qin Zhi-Qiang ZQ Zhang Jian-Zhong JZ He Yuan Y Wu Peng-Fei PF Miao Yi Y Jiang Kui-Rong KR
Oncotarget 20170701 30
Single nucleotide polymorphisms (SNPs) of Excision repair cross-complementing group 2 (ERCC2) gene are suspected to affect the risk of pancreatic cancer. Many studies have reported the association between ERCC2 Lys751Gln polymorphism (rs13181) and the susceptibility to pancreatic cancer, but the outcomes remained controversial. To comprehensively determine this association, we conducted a meta-analysis based on a total of eight studies. Evidence for this association was obtained from the PubMed, ...[more]