RORγt-expressing cells attenuate cardiac remodeling after myocardial infarction.

ABSTRACT:

Aims

Retinoic acid receptor-related orphan nuclear receptor γt (RORγt) is a transcriptional factor responsible for IL-17-producing T-cell differentiation. Although it was demonstrated that RORγt plays essential roles in the onset of autoimmune myocarditis, pathophysiological significance of RORγt in cardiac remodeling after myocardial infarction (MI) remains to be fully elucidated.

Methods and results

MI was generated by ligating coronary artery. The expression of RORγt and IL-17A transcripts increased in murine hearts after MI. Additionally, immunohistochemical staining revealed that RORγt-expressing cells infiltrated in the border zone after MI. Flow cytometric analysis showed that RORγt-expressing cells were released from the spleen at day 1 after MI. Though RORγt-express

SUBMITTER: Enomoto D 

PROVIDER: S-EPMC5565178 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature