Dataset Information

Timing and rate of spheno-occipital synchondrosis closure and its relationship to puberty.

ABSTRACT:

Objectives

This study examines the relationship between spheno-occipital synchondrosis (SOS) closure and puberty onset in a modern American population. It also investigates the timing and the rate of SOS closure in males and females.

Materials and methods

The sample includes cross-sectional and longitudinal 3D Cone Beam Computed Tomography (CBCT) scans of 741 individuals (361 males and 380 females) aged 6-20 years. Each CBCT scan is visualized in the mid-sagittal plane, and the spheno-occipital synchondrosis (SOS) is scored as completely open, partially fused, mostly fused, and completely fused. The Menarche commencement is used as an indicator of puberty onset in females.

Results

Mean ages of open, partially-fused, mostly-fused, and completely fused SOS were 11.07, 12.95, 14.44, and 16.41 years in males, and 9.75, 11.67, 13.25, and 15.25 in females, respectively. The results show there is a significant association between the SOS closure stage and the commencement of menarche (Fisher's Exact Test p < 0.001). It was found that females had a higher SOS closure rate (38.60%) per year than males at the age of 10 years. The closure rate in males appears slower than females at age 10, but it lasts a longer time, ranging between 22 and 26% per year from age 11 to 14 years.

Conclusion

There is a significant relationship between puberty onset and SOS closure, suggesting its closure is at least partially affected by systemic, hormonal changes in the growing adolescent. Also, SOS closure occurs at a faster rate and at an earlier age in females compared to males.

SUBMITTER: Alhazmi A

PROVIDER: S-EPMC5565182 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature

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Publications

Timing and rate of spheno-occipital synchondrosis closure and its relationship to puberty.

Alhazmi Anwar A Vargas Eduardo E Palomo J Martin JM Hans Mark M Latimer Bruce B Simpson Scott S

PloS one 20170821 8

<h4>Objectives</h4>This study examines the relationship between spheno-occipital synchondrosis (SOS) closure and puberty onset in a modern American population. It also investigates the timing and the rate of SOS closure in males and females.<h4>Materials and methods</h4>The sample includes cross-sectional and longitudinal 3D Cone Beam Computed Tomography (CBCT) scans of 741 individuals (361 males and 380 females) aged 6-20 years. Each CBCT scan is visualized in the mid-sagittal plane, and the sp ...[more]

PMID: 28827837

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Project description:It is well known that excess adiposity during childhood may influence pubertal development. However, the extent to which body compositions vary in throughout puberty in boys and girls is currently unknown. The aim of this study was to investigate whether obesity and body compositions correlate with the timing of puberty in boys and girls.By random cluster sampling, our study analyzed data from 1472 students (690 girls, 782 boys) aged 6-17 years from two schools in the Chongqing area. Data were collected by physical examination of weight, height, and skinfold thicknesses. Testicular volume was measured in boys and breast development in girls. By which we got the indicators of obesity, timing of puberty and body compositions. Probit regression analysis was used to group subjects into early puberty (>P25), on-time puberty (P25 ~ P75), and delayed puberty (<P75). Chi-square test was applied to assess the distribution differences of fat levels among puberty groups by sex. Multivariate analysis of covariance was used to examine the association between timing of puberty and body composition indicators.There were significant differences in the distribution of fat levels (normal weigh, overweight, obesity) among different pubertal groups in different sex (boys:χ2 = 10.639, P = 0.031; girls:χ2 = 63.232, P = 0.000). Multivariate analysis of covariance showed that percentage of body fat, fat mass and fat-free mass in the delayed puberty girls were significantly lower than the girls in the on-time puberty and early puberty, while body density had the opposite result (all P < 0.001). Body density, percentage of body fat, fat mass and fat-free mass of boys all had no significant difference among different timing of puberty groups (all P > 0.05).In girls, delayed puberty was negatively correlated with Obesity, percentage of body fat, fat mass and fat-free mass, and positively correlated with body density. But in boys, delayed puberty was only negatively correlated with Obesity, the relation between puberty and body compositions was not found.

Dataset Information

Timing and rate of spheno-occipital synchondrosis closure and its relationship to puberty.

Objectives

Materials and methods

Results

Conclusion

Publications

Timing and rate of spheno-occipital synchondrosis closure and its relationship to puberty.

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