Ontology highlight
ABSTRACT:
SUBMITTER: Eagen KP
PROVIDER: S-EPMC5565414 | biostudies-literature | 2017 Aug
REPOSITORIES: biostudies-literature
Proceedings of the National Academy of Sciences of the United States of America 20170801 33
The locations of chromatin loops in <i>Drosophila</i> were determined by Hi-C (chemical cross-linking, restriction digestion, ligation, and high-throughput DNA sequencing). Whereas most loop boundaries or "anchors" are associated with CTCF protein in mammals, loop anchors in <i>Drosophila</i> were found most often in association with the polycomb group (PcG) protein Polycomb (Pc), a subunit of polycomb repressive complex 1 (PRC1). Loops were frequently located within domains of PcG-repressed chr ...[more]