Ontology highlight
ABSTRACT:
SUBMITTER: Zhu W
PROVIDER: S-EPMC5566107 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Zhu Wenzhuo W Li Zhao Z Xiong Liwen L Yu Xiaobo X Chen Xi X Lin Qiang Q
Theranostics 20170722 12
FKBP3 is a member of FK506-binding proteins (FKBPs). Little is known about the expression and functional role(s) of FKBP3 in non-small cell lung cancer (NSCLC). In the present study, we demonstrated up-regulation of FKBP3 expression, both at mRNA and protein levels, in NSCLC samples which closely correlated with poor survival in NSCLC patients. <i>In vitro</i> and <i>in vivo</i> experiments revealed that FKBP3 could promote NSCLC cell proliferation. Furthermore, knockdown of FKBP3 significantly ...[more]