Ontology highlight
ABSTRACT:
SUBMITTER: Westacott MJ
PROVIDER: S-EPMC5566297 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Westacott Matthew J MJ Farnsworth Nikki L NL St Clair Joshua R JR Poffenberger Greg G Heintz Audrey A Ludin Nurin W NW Hart Nathaniel J NJ Powers Alvin C AC Benninger Richard K P RKP
Diabetes 20170606 9
Aging is associated with increased risk for type 2 diabetes, resulting from reduced insulin sensitivity and secretion. Reduced insulin secretion can result from reduced proliferative capacity and reduced islet function. Mechanisms underlying altered β-cell function in aging are poorly understood in mouse and human islets, and the impact of aging on intraislet communication has not been characterized. Here, we examine how β-cell [Ca<sup>2+</sup>] and electrical communication are impacted during a ...[more]