Ontology highlight
ABSTRACT:
SUBMITTER: Bignon E
PROVIDER: S-EPMC5566383 | biostudies-literature | 2017 Aug
REPOSITORIES: biostudies-literature
Bignon Emmanuelle E Marazzi Marco M Besancenot Vanessa V Gattuso Hugo H Drouot Guillaume G Morell Christophe C Eriksson Leif A LA Grandemange Stephanie S Dumont Elise E Monari Antonio A
Scientific reports 20170821 1
Nonsteroidal 2-arylproprionic acids are widely used, over-the-counter, anti-inflammatory drugs. Photosensitivity is a commonly overlooked adverse effect of these drugs. Based on the combined use of cell viability assays and molecular modeling, we prove and rationalize the photochemical pathways triggering photosensitization for two drugs, ibuprofen and ketoprofen. As its parent compound benzophenone, ketoprofen produces singlet oxygen, upon triplet manifold population. However, ibuprofen and ket ...[more]