Ontology highlight
ABSTRACT:
SUBMITTER: Liao W
PROVIDER: S-EPMC5566403 | biostudies-literature | 2017 Aug
REPOSITORIES: biostudies-literature
Liao Wenjuan W Liu Hongbing H Zhang Yiwei Y Jung Ji Hoon JH Chen Jiaxiang J Su Xiaohua X Kim Yeong C YC Flores Elsa R ER Wang San Ming SM Czarny-Ratajczak Malwina M Li Wen W Zeng Shelya X SX Lu Hua H
Scientific reports 20170821 1
TAp63, a member of the p53 family, has been shown to regulate energy metabolism. Here, we report coiled coil domain-containing 3 (CCDC3) as a new TAp63 target. TAp63, but not ΔNp63, p53 or p73, upregulates CCDC3 expression by directly binding to its enhancer region. The CCDC3 expression is markedly reduced in TAp63-null mouse embryonic fibroblasts and brown adipose tissues and by tumor necrosis factor alpha that reduces p63 transcriptional activity, but induced by metformin, an anti-diabetic dru ...[more]