Ontology highlight
ABSTRACT:
SUBMITTER: Patel SH
PROVIDER: S-EPMC5566418 | biostudies-literature | 2017 Aug
REPOSITORIES: biostudies-literature
Patel Saloni H SH O'Hara Laura L Atanassova Nina N Smith Sarah E SE Curley Michael K MK Rebourcet Diane D Darbey Annalucia L AL Gannon Anne-Louise AL Sharpe Richard M RM Smith Lee B LB
Scientific reports 20170821 1
The tamoxifen-inducible Cre system is a popular transgenic method for controlling the induction of recombination by Cre at a specific time and in a specific cell type. However, tamoxifen is not an inert inducer of recombination, but an established endocrine disruptor with mixed agonist/antagonist activity acting via endogenous estrogen receptors. Such potentially confounding effects should be controlled for, but >40% of publications that have used tamoxifen to generate conditional knockouts have ...[more]