High-intensity training enhances executive function in children in a randomized, placebo-controlled trial.

ABSTRACT: Background:Exercise-induced cognitive improvements have traditionally been observed following aerobic exercise interventions; that is, sustained sessions of moderate intensity. Here, we tested the effect of a 6 week high-intensity training (HIT) regimen on measures of cognitive control and working memory in a multicenter, randomized (1:1 allocation), placebo-controlled trial. Methods:318 children aged 7-13 years were randomly assigned to a HIT or an active control group matched for enjoyment and motivation. In the primary analysis, we compared improvements on six cognitive tasks representing two cognitive constructs (N = 305). Secondary outcomes included genetic data and physiological measurements. Results:The 6-week HIT regimen resulted in improvements on measures of cognitive control [BFM = 3.38, g = 0.31 (0.09, 0.54)] and working memory [BFM = 5233.68, g = 0.54 (0.31, 0.77)], moderated by BDNF genotype, with met66 carriers showing larger gains post-exercise than val66 homozygotes. Conclusions:This study suggests a promising alternative to enhance cognition, via short and potent exercise regimens. Funding:Funded by Centre for Brain Research. Clinical trial number:NCT03255499.

SUBMITTER: Moreau D 

PROVIDER: S-EPMC5566451 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature