Dataset Information

Cabazitaxel in the treatment of metastatic castration-resistant prostate cancer: patient selection and special considerations.

ABSTRACT: Cabazitaxel is an effective chemotherapeutic agent used in the treatment of metastatic castration-resistant prostate cancer (mCRPC) refractory to docetaxel. With the advent of new antiandrogen therapies, immune-based treatments, and radioactive-targeted therapy, there are now multiple effective and approved agents for this disease state. The optimal sequencing of these agents is unclear as there are no large-scale head-to-head comparisons. Clinicians must familiarize themselves with the most recent studies as well as drug toxicities to determine the best treatment option for their patients. In this review, we focus on the development of cabazitaxel for mCRPC, evaluate its efficacy, and highlight key strategies for toxicity management. Additionally, we summarize the studies that address cabazitaxel treatment sequencing and optimal dosing schedule.

SUBMITTER: Patel SA

PROVIDER: S-EPMC5566506 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature

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Cabazitaxel in the treatment of metastatic castration-resistant prostate cancer: patient selection and special considerations.

Patel Sheel A SA Hoffman-Censits Jean J

OncoTargets and therapy 20170817

Cabazitaxel is an effective chemotherapeutic agent used in the treatment of metastatic castration-resistant prostate cancer (mCRPC) refractory to docetaxel. With the advent of new antiandrogen therapies, immune-based treatments, and radioactive-targeted therapy, there are now multiple effective and approved agents for this disease state. The optimal sequencing of these agents is unclear as there are no large-scale head-to-head comparisons. Clinicians must familiarize themselves with the most rec ...[more]

PMID: 28860817

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Dataset Information

Cabazitaxel in the treatment of metastatic castration-resistant prostate cancer: patient selection and special considerations.

Publications

Cabazitaxel in the treatment of metastatic castration-resistant prostate cancer: patient selection and special considerations.

Similar Datasets

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