Dataset Information

Selective impact of disease on short-term and long-term components of self-reported memory: a population-based HUNT study.

ABSTRACT:

Background

Subjective memory is commonly considered to be a unidimensional measure. However, theories of performance-based memory suggest that subjective memory could be divided into more than one dimension.

Objective

To divide subjective memory into theoretically related components of memory and explore the relationship to disease.

Methods

In this study, various aspects of self-reported memory were studied with respect to demographics and diseases in the third wave of the HUNT epidemiological study in middle Norway. The study included all individuals 55 years of age or older, who responded to a nine-item questionnaire on subjective memory and questionnaires on health (n=18?633).

Results

A principle component analysis of the memory items resulted in two memory components; the criterion used was an eigenvalue above 1, which accounted for 54% of the total variance. The components were interpreted as long-term memory (LTM; the first component; 43% of the total variance) and short-term memory (STM; the second component; 11% of the total variance). Memory impairment was significantly related to all diseases (except Bechterew's disease), most strongly to brain infarction, heart failure, diabetes, cancer, chronic obstructive pulmonary disease and whiplash. For most diseases, the STM component was more affected than the LTM component; however, in cancer, the opposite pattern was seen.

Conclusions

Subjective memory impairment as measured in HUNT contained two components, which were differentially associated with diseases.

SUBMITTER: Almkvist O

PROVIDER: S-EPMC5566596 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature

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Publications

Selective impact of disease on short-term and long-term components of self-reported memory: a population-based HUNT study.

Almkvist Ove O Bosnes Ole O Bosnes Ingunn I Stordal Eystein E

BMJ open 20170509 5

<h4>Background</h4>Subjective memory is commonly considered to be a unidimensional measure. However, theories of performance-based memory suggest that subjective memory could be divided into more than one dimension.<h4>Objective</h4>To divide subjective memory into theoretically related components of memory and explore the relationship to disease.<h4>Methods</h4>In this study, various aspects of self-reported memory were studied with respect to demographics and diseases in the third wave of the ...[more]

PMID: 28490551

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Project description:A distinction has always been made between long-term and short-term memory (also now called working memory, WM). The obvious difference between these two kinds of memory concerns the duration of information storage: information is supposedly transiently stored in WM while it is considered durably consolidated into long-term memory. It is well acknowledged that the content of WM is erased and reset after a short time, to prevent irrelevant information from proactively interfering with newly stored information. In the present study, we used typical WM radial maze tasks to question the brief lifespan of spatial WM content in rodents. Groups of rats were submitted to one of two different WM tasks in a radial maze: a WM task involving the repetitive presentation of a same pair of arms expected to induce a high level of proactive interference (PI) (HIWM task), or a task using a different pair in each trial expected to induce a low level of PI (LIWM task). Performance was effectively lower in the HIWM group than in LIWM in the final trial of each training session, indicative of a "within-session/short-term" PI effect. However, we also observed a different "between-session/long-term" PI effect between the two groups: while performance of LIWM trained rats remained stable over days, the performance of HIWM rats dropped after 10 days of training, and this impairment was visible from the very first trial of the day, hence not attributable to within-session PI. We also showed that a 24 hour-gap across training sessions known to allow consolidation processes to unfold, was a necessary and sufficient condition for the long-term PI effect to occur. These findings suggest that in the HIWM task, WM content was not entirely reset between training sessions and that, in specific conditions, WM content can outlast its purpose by being stored more permanently, generating a long-term deleterious effect of PI. The alternative explanation is that WM content could be transferred and stored more permanently in an intermediary form or memory between WM and long-term memory.

Dataset Information

Selective impact of disease on short-term and long-term components of self-reported memory: a population-based HUNT study.

Background

Objective

Methods

Results

Conclusions

Publications

Selective impact of disease on short-term and long-term components of self-reported memory: a population-based HUNT study.

Similar Datasets

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