Dataset Information

Associations between lead concentrations and cardiovascular risk factors in U.S. adolescents.

ABSTRACT: Little is known regarding the effects of environmental lead exposure on cardiovascular risk factors in the adolescent population. We studied 11,662 subjects included in the National Health and Nutrition Examination Survey (NHANES) 1999-2012. Blood lead levels were analysed for their association with cardiovascular risk factors (CVRF). Regression coefficients (Beta) and 95% confidence intervals (CIs) of blood lead in association with CVRF (e.g., total cholesterol, HDL-cholesterol, LDL-cholesterol, triglyceride, fasting glucose, glycohemoglobin, fasting insulin, and blood pressure) were estimated using multivariate and generalized linear regression after adjusting for age, gender, ethnicity, serum cotinine, body mass index (BMI), physical activity, and household income. We identified a strong positive association between blood lead (coefficient?=?0.022, 95% CI 0.003, 0.041; P?=?0.022) and LDL-cholesterol in adolescents (age 12-19 years). However, no associations with other CVRFs were found in the overall population. In the generalized linear models, participants with the highest lead levels demonstrated a 1.87% (95% CI 0.73%, 3.02%) greater increase in serum LDL-cholesterol (p for trend?=?0.031) when compared to participants with the lowest lead levels. These results provide epidemiological evidence that low levels of blood lead are positively associated with LDL-cholesterol in the adolescent population.

SUBMITTER: Xu C

PROVIDER: S-EPMC5567237 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Associations between lead concentrations and cardiovascular risk factors in U.S. adolescents.

Xu Cheng C Shu Yaqin Y Fu Zhi Z Hu Yuanli Y Mo Xuming X

Scientific reports 20170822 1

Little is known regarding the effects of environmental lead exposure on cardiovascular risk factors in the adolescent population. We studied 11,662 subjects included in the National Health and Nutrition Examination Survey (NHANES) 1999-2012. Blood lead levels were analysed for their association with cardiovascular risk factors (CVRF). Regression coefficients (Beta) and 95% confidence intervals (CIs) of blood lead in association with CVRF (e.g., total cholesterol, HDL-cholesterol, LDL-cholesterol ...[more]

PMID: 28831128

Similar Datasets

Project description:INTRODUCTION:The occurrence of cardiovascular diseases and metabolic disorders steadily increases with the body mass index (BMI). Since the latter is not the best and earliest indicator of obesity and cardiovascular risk, the aim of the study was to evaluate some potential biological markers that would allow us to detect children and adolescents at higher risk at an early stage. METHODS:A sample of 330 children and adolescents were included in the study and divided into four groups: obese patients with hypertension, normal-weight patients with hypertension, patients with mildly elevated lipids and a control group of healthy children and adolescents. Some clinical parameters (age, body weight, body height, BMI, waist circumference, hip circumference, blood pressure), biochemical parameters (glucose, total cholesterol, triglycerides, HDL, LDL, apolipoprotein A1, homocysteine) and biological markers of obesity (ghrelin, adiponectin, leptin) were evaluated. RESULTS:Ghrelin and adiponectin were found to have a strong negative statistically significant correlation with BMI in all three observed groups (p?<?0.001), but not in the control group (p?=?0.053 and p?=?0.316, respectively). In addition, leptin had a strong positive statistically significant correlation with BMI in all four groups (p?<?0.001 for the research groups, p?=?0.009 for the controls). In the group of obese patients with hypertension, statistically significant differences in all three markers of obesity were found in comparison to the control group (p?<?0.001 for all markers). In the group of patients with mildly elevated lipids, ghrelin and leptin were significantly different (p?=?0.002 and p?<?0.001, respectively). In the group of normal-weight hypertensive patients, only values of ghrelin were different compared to the control group (p?=?0.001). CONCLUSION:In the research groups, significant differences were found in clinical, biochemical and biological parameters compared to the control group. The observed biological markers of obesity are useful early markers for identifying groups of patients that are at cardiovascular risk.

Dataset Information

Associations between lead concentrations and cardiovascular risk factors in U.S. adolescents.

Publications

Associations between lead concentrations and cardiovascular risk factors in U.S. adolescents.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets