Ontology highlight
ABSTRACT:
SUBMITTER: Pan X
PROVIDER: S-EPMC5567484 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
Pan Xiaoli X Chen Zhichun Z Fei Guoqiang G Pan Shumei S Bao Weiqi W Ren Shuhua S Guan Yihui Y Zhong Chunjiu C
Neuroscience bulletin 20161001 6
To date, we still lack disease-modifying therapies for Alzheimer's disease (AD). Here, we report that long-term administration of benfotiamine improved the cognitive ability of patients with AD. Five patients with mild to moderate AD received oral benfotiamine (300 mg daily) over 18 months. All patients were examined by positron emission tomography with Pittsburgh compound B (PiB-PET) and exhibited positive imaging with β-amyloid deposition, and three received PiB-PET imaging at follow-up. The f ...[more]