Ontology highlight
ABSTRACT:
SUBMITTER: Peana D
PROVIDER: S-EPMC5567788 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
Peana Deborah D Domeier Timothy L TL
Current opinion in pharmacology 20170422
Heart failure is a highly prevalent syndrome of multiple etiologies and associated comorbidities, and aberrant intracellular Ca<sup>2+</sup> homeostasis is a hallmark finding in heart failure patients. The cyclical changes in Ca<sup>2+</sup> concentration within cardiomyocytes control cycles of cardiac contraction and relaxation, and dysregulation of Ca<sup>2+</sup> handling processes leads to systolic dysfunction, diastolic dysfunction, and adverse remodeling. For this reason, greater understan ...[more]