Ontology highlight
ABSTRACT:
SUBMITTER: Iwata-Otsubo A
PROVIDER: S-EPMC5567862 | biostudies-literature | 2017 Aug
REPOSITORIES: biostudies-literature
Current biology : CB 20170727 15
Female meiosis provides an opportunity for selfish genetic elements to violate Mendel's law of segregation by increasing the chance of segregating to the egg [1]. Centromeres and other repetitive sequences can drive in meiosis by cheating the segregation process [2], but the underlying mechanisms are unknown. Here, we show that centromeres with more satellite repeats house more nucleosomes that confer centromere identity, containing the histone H3 variant CENP-A, and bias their segregation to th ...[more]