Impact of post-dialysis calcium level on ex vivo rat aortic wall calcification.

ABSTRACT:

Objectives

Vascular calcification is a frequent complication in chronic haemodialysis patients and is associated with adverse outcomes. Serum calcium and phosphate levels and imbalances in calcification regulators are thought to contribute to the process. In this regard, the dialysate calcium concentration is a modifiable tool for modulating the risk of vascular calcification. We explored pre- and post-dialysis phosphate and calcium concentrations in stable chronic haemodialysis patients treated by dialysis with the KDIGO-suggested 1.5 mmol/L calcium dialysate to investigate the effects on ex vivo calcification of rat aortic rings.

Approach and results

At the end of haemodialysis, mean serum calcium levels were increased in 88% of paired pre-/post-dialysis samples, while mea

SUBMITTER: Azpiazu D 

PROVIDER: S-EPMC5568142 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature