The remnant of the European rabbit (Oryctolagus cuniculus) IgD gene.
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ABSTRACT:
SUBMITTER: Lanning DK
PROVIDER: S-EPMC5568218 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Publications
The remnant of the European rabbit (Oryctolagus cuniculus) IgD gene.
Lanning Dennis K DK Esteves Pedro J PJ Knight Katherine L KL
PloS one 20170823 8
Although IgD first appeared, along with IgM, in the cartilaginous fishes and has been retained throughout subsequent vertebrate evolution, it has been lost in a diverse group of vertebrate species. We previously showed that, unlike vertebrates that express IgD, the rabbit lacks an IgD (Cδ) gene within 13.5 kb downstream of the IgM gene. We report here that, by conducting BLAST searches of rabbit Ig heavy chain genomic DNA with known mammalian IgD exons, we identified the remnant of the rabbit Cδ ...[more]
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