Ontology highlight
ABSTRACT:
SUBMITTER: Huang AY
PROVIDER: S-EPMC5568251 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
Neuron 20170601 6
Tourette syndrome (TS) is a model neuropsychiatric disorder thought to arise from abnormal development and/or maintenance of cortico-striato-thalamo-cortical circuits. TS is highly heritable, but its underlying genetic causes are still elusive, and no genome-wide significant loci have been discovered to date. We analyzed a European ancestry sample of 2,434 TS cases and 4,093 ancestry-matched controls for rare (< 1% frequency) copy-number variants (CNVs) using SNP microarray data. We observed an ...[more]