Ontology highlight
ABSTRACT:
SUBMITTER: Shen Y
PROVIDER: S-EPMC5568495 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Shen Yi Y Wen Zhenke Z Li Yinyin Y Matteson Eric L EL Hong Jison J Goronzy Jörg J JJ Weyand Cornelia M CM
Nature immunology 20170724 9
Pathogenic T cells in individuals with rheumatoid arthritis (RA) infiltrate non-lymphoid tissue sites, maneuver through extracellular matrix and form lasting inflammatory microstructures. Here we found that RA T cells abundantly express the podosome scaffolding protein TKS5, which enables them to form tissue-invasive membrane structures. TKS5 overexpression was regulated by the intracellular metabolic environment of RA T cells-specifically, by reduced glycolytic flux that led to deficiencies in ...[more]