Ontology highlight
ABSTRACT: Objective
Genome-wide association studies (GWAS) of gastric cancer have reported differences in single-nucleotide polymorphism (SNP) associations for tumour subtypes, particularly when divided by location into the gastric cardia versus the non-cardia.Design
Here we present results for a GWAS using 2350 East Asian gastric cancer cases divided as 1189 gastric cardia and 1027 gastric non-cardia cases and 2708 controls. We also included up to 3042 cardia cases, 4359 non-cardia cases and 7548 controls for replication from two Chinese studies and one Korean study. From the GWAS, we selected 12 top SNPs for each gastric cancer subtype, 4 top SNPs for total gastric cancer and 1 SNP in MUC1 for replication testing.Results
We observed genome-wide significant associations for rs10074991 in PRKAA1 at 5p13.1 for cardia (p=7.36×10(-12)) and non-cardia cancers (p=2.42×10(-23)) with per allele OR (95% CI) for the combined endpoint of 0.80 (0.77 to 0.83). At 6p21.1, rs2294693 near UNC5CL was significantly associated with gastric non-cardia cancer risk (p=2.50×10(-8)), with OR (95% CI) of 1.18 (1.12 to 1.26), but there was only a nominal association for cardia cancer (p=1.47×10(-2)). We also confirmed a previously reported association for rs4072037 in MUC1 with p=6.59×10(-8) for total gastric cancer and similar estimates for cardia and non-cardia cancers. Three SNPs in PSCA previously reported to be associated with gastric non-cardia cancer showed no apparent association for cardia cancer.Conclusions
Our results suggest that associations for SNPs with gastric cancer show some different results by tumour location in the stomach.
SUBMITTER: Hu N
PROVIDER: S-EPMC5568652 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
Hu Nan N Wang Zhaoming Z Song Xin X Wei Lixuan L Kim Byung Sik BS Freedman Neal D ND Baek Jiwon J Burdette Laurie L Chang Jiang J Chung Charles C Dawsey Sanford M SM Ding Ti T Gao Yu-Tang YT Giffen Carol C Han Yaling Y Hong Myunghee M Huang Jia J Kim Hee Sung HS Koh Woon-Puay WP Liao Linda M LM Mao Yi Min YM Qiao You-Lin YL Shu Xiao-Ou XO Tan Wen W Wang Chaoyu C Wu Chen C Wu Min-Jie MJ Xiang Yong-Bing YB Yeager Meredith M Yook Jeong Hwan JH Yuan Jian-Min JM Zhang Peng P Zhao Xue-Ke XK Zheng Wei W Song Kyuyoung K Wang Li-Dong LD Lin Dongxin D Chanock Stephen J SJ Goldstein Alisa M AM Taylor Philip R PR Abnet Christian C CC
Gut 20150630 10
<h4>Objective</h4>Genome-wide association studies (GWAS) of gastric cancer have reported differences in single-nucleotide polymorphism (SNP) associations for tumour subtypes, particularly when divided by location into the gastric cardia versus the non-cardia.<h4>Design</h4>Here we present results for a GWAS using 2350 East Asian gastric cancer cases divided as 1189 gastric cardia and 1027 gastric non-cardia cases and 2708 controls. We also included up to 3042 cardia cases, 4359 non-cardia cases ...[more]