Ontology highlight
ABSTRACT:
SUBMITTER: Zagorski M
PROVIDER: S-EPMC5568706 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
Zagorski Marcin M Tabata Yoji Y Brandenberg Nathalie N Lutolf Matthias P MP Tkačik Gašper G Bollenbach Tobias T Briscoe James J Kicheva Anna A
Science (New York, N.Y.) 20170601 6345
Like many developing tissues, the vertebrate neural tube is patterned by antiparallel morphogen gradients. To understand how these inputs are interpreted, we measured morphogen signaling and target gene expression in mouse embryos and chick ex vivo assays. From these data, we derived and validated a characteristic decoding map that relates morphogen input to the positional identity of neural progenitors. Analysis of the observed responses indicates that the underlying interpretation strategy min ...[more]