Ontology highlight
ABSTRACT:
SUBMITTER: Hu X
PROVIDER: S-EPMC5568789 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Hu Xiuli X Yu Jicheng J Qian Chenggen C Lu Yue Y Kahkoska Anna R AR Xie Zhigang Z Jing Xiabin X Buse John B JB Gu Zhen Z
ACS nano 20170104 1
A self-regulated "smart" insulin administration system would be highly desirable for diabetes management. Here, a glucose-responsive insulin delivery device, which integrates H<sub>2</sub>O<sub>2</sub>-responsive polymeric vesicles (PVs) with a transcutaneous microneedle-array patch was prepared to achieve a fast response, excellent biocompatibility, and painless administration. The PVs are self-assembled from block copolymer incorporated with polyethylene glycol (PEG) and phenylboronic ester (P ...[more]