Ontology highlight
ABSTRACT:
SUBMITTER: Ranjbarvaziri S
PROVIDER: S-EPMC5568924 | biostudies-literature | 2017 Aug
REPOSITORIES: biostudies-literature
Ranjbarvaziri Sara S Park Shuin S Nguyen Ngoc B NB Gilmore William B WB Zhao Peng P Ardehali Reza R
Genesis (New York, N.Y. : 2000) 20170615 8
Nkx2-5 is a homeobox-containing transcriptional regulator that serves as one of the earliest markers of cardiac lineage commitment. To study the role of Nkx2-5-expressing progenitors at specific time points in cardiac development, we have generated a novel and inducible NKX2-5 mouse line by knocking in a CreER cassette into the Nkx2-5 genomic locus, while preserving the endogenous Nkx2-5 gene to avoid haploinsufficiency. We evaluated the specificity and efficiency of CreER activity after 4-OHT i ...[more]