Ontology highlight
ABSTRACT:
SUBMITTER: Daver N
PROVIDER: S-EPMC5568927 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Daver Naval N McClain Kenneth K Allen Carl E CE Parikh Sameer A SA Otrock Zaher Z Rojas-Hernandez Cristhiam C Blechacz Boris B Wang Sa S Minkov Milen M Jordan Michael B MB La Rosée Paul P Kantarjian Hagop M HM
Cancer 20170616 17
Hemophagocytic lymphohistiocytosis (HLH) is a syndrome of severe immune activation and dysregulation resulting in extreme and often life-threatening inflammation. HLH has been well recognized in pediatric populations, and most current diagnostic and therapeutic guidelines are based on pediatric HLH. Recently there has been recognition of HLH in adults, especially secondary to immune deregulation by an underlying rheumatologic, infectious, or malignant condition. This review is focused on maligna ...[more]