Clinical and metabolic correlates of cerebral calcifications in Sturge-Weber syndrome.

ABSTRACT:

Aim

To evaluate clinical and metabolic correlates of cerebral calcifications in children with Sturge-Weber syndrome (SWS).

Method

Fifteen children (11 females, four males; age range 7mo-9y, mean 4y 1mo) with unilateral SWS underwent baseline and follow-up magnetic resonance imaging (MRI) with susceptibility weighted imaging (SWI), glucose metabolism positron emission tomography (PET), and neurocognitive assessment (mean follow-up 1y 8mo). Calcified brain volumes measured on SWI were correlated with areas of abnormal glucose metabolism, seizure variables, and cognitive function (IQ).

Results

Ten children had brain calcification at baseline and 11 at follow-up. Mean calcified brain volume increased from 1.69 to 2.47cm³ (p=0.003) in these children; the rate of

SUBMITTER: Pilli VK 

PROVIDER: S-EPMC5568960 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature