Ontology highlight
ABSTRACT:
SUBMITTER: Miranda D
PROVIDER: S-EPMC5568974 | biostudies-literature | 2017 Aug
REPOSITORIES: biostudies-literature
Miranda Dyego D Carter Kevin K Luo Dandan D Shao Shuai S Geng Jumin J Li Changning C Chitgupi Upendra U Turowski Steven G SG Li Nasi N Atilla-Gokcumen G Ekin GE Spernyak Joseph A JA Lovell Jonathan F JF
Advanced healthcare materials 20170515 16
Intratumoral (IT) drug injections reduce systemic toxicity, but delivered volumes and distribution can be inconsistent. To improve IT delivery paradigms, porphyrin-phospholipid (PoP) liposomes are passively loaded with three hydrophilic cargos: sulforhodamine B, a fluorophore; gadolinium-gadopentetic acid, a magnetic resonance (MR) agent; and oxaliplatin, a colorectal cancer chemotherapeutic. Liposome composition is optimized so that cargo is retained in serum and storage, but is released in les ...[more]